A hybrid discrete-continuum model of immune responses to SARS-CoV-2 infection in the lung alveolar region, with a focus on interferon induced innate responseArticle Published on 2022-12-212022-11-15 Journal: Journal of theoretical biology [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] adaptive alveolar alveolar cells antibodies antibody antibody concentration baseline Cell cell death Cellular automaton COVID-19 develop diffusion domain Efficacy Future Gas exchange healthy human lung Immune cell immune protection immune response Immunity infected cell Infection initial Innate innate immune Innate immunity innate response Interaction interferon interferons lung alveolar maintain manuscript mechanism Model multiple mechanism outcome Pneumonia produced profiles progression Result RNA copy SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant simulations. Spread Strains submitted switching T cells the SARS-CoV-2 virus two-dimensional type I Viral load virion virions [DOI] 10.1016/j.jtbi.2022.111293 PMC 바로가기
Human-Immune-System (HIS) humanized mouse model (DRAGA: HLA-A2.HLA-DR4.Rag1KO.IL-2RγcKO.NOD) for COVID-19COVID-19에 대한 인간 면역 시스템(HIS) 인간화 마우스 모델(DRAGA: HLA-A2.HLA-DR4.Rag1KO.IL-2RγcKO.NOD)Article Published on 2022-11-302022-09-11 Journal: Human vaccines & immunotherapeutics [Category] SARS, 유전자 메커니즘, [키워드] Anti-viral B cell Blood candidate vaccine CD4 CD8 Cell clinical condition Cord blood COVID-19 COVID-19 research cytotoxic activity DRAGA mice Efficacy epithelial Express expressing functional granzyme B Hematopoietic stem cell Human human ACE2 receptor human antibodies Human immune system human lung-resident CD8 T cells humanized humanized mice IgG antibody immune immunopathological in vivo infused intra-alveolar lung lung immunopathology lung immunopathology. Lungs lymphocyte mechanism mice microthrombi mounted perforin promote Proteins replicating virus response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral secreted surrogate switching System T cell T cells Therapeutics unique upper respiratory airway Viral proteins [DOI] 10.1080/21645515.2022.2048622 PMC 바로가기 [Article Type] Article
Rapid Evaluation of Vaccine Booster Effectiveness against SARS-CoV-2 VariantsArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] 95% CI appear applied approach Blood booster booster vaccination Booster vaccine Cellulose country COVID COVID-19 pandemic decrease evaluate evaluated heterogeneity immune response Immunity immunological protection increase in indicated individual individual level induce median MONITOR NAb Neutralization antibody Neutralizing Neutralizing antibodies neutralizing antibody omicron Omicron variant pandemic POC point of care point-of-care point-of-care test. population level predominant Protective Rapid regimen reported responses against SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants shown stick switching vaccination variant variants of concern variants of SARS-CoV-2 virus neutralization test VoC VOCs waning immunity wild-type [DOI] 10.1128/spectrum.02257-22 PMC 바로가기
Mass Switch From Intravenous to Subcutaneous Tocilizumab in Rheumatic Diseases During the SARS-COV-2 PandemicArticle Published on 2022-10-012022-11-15 Journal: Journal of clinical rheumatology : practical reports on rheumatic & [Category] COVID19(2023년), SARS, 진단, [키워드] administration adverse event Analysis Cell COVID Critical disease effective Follow-up Giant giant cell arteritis headache hospital injection intravenous juvenile idiopathic arthritis mass pandemic Patient remained rheumatoid arthritis rheumatological patient rheumatology Safe Subcutaneous subgroup analysis switch switching Systemic sclerosis TCZ the SARS-CoV-2 Tocilizumab Treatment was performed [DOI] 10.1097/RHU.0000000000001862 PMC 바로가기
Antiretroviral drug switches to zidovudine-based regimens and loss to follow-up during the first COVID-19 lockdown in Bali, IndonesiaArticle Published on 2022-10-012022-11-15 Journal: HIV medicine [Category] 치료제, [키워드] anonymized data antiretroviral antiretroviral drug antiretroviral treatment ART Care collected Combination COVID-19 COVID-19 pandemic demographic data diagnosed drug resistance effort Follow-up greater had no HIV impacted Indonesia information International Laboratory testing lockdown Lockdown. majority men National numbers of patient Patient Record regimen regimens Registered required retrospective Sex Support switching Toxicity Treatment Viral load virological suppression with HIV [DOI] 10.1111/hiv.13298 PMC 바로가기
Evaluation of a new “all in one” SARS-CoV-2 antigen-detecting rapid diagnostic test and self-test: Diagnostic performance and usability in child and adult populations새로운 "올인원" SARS-CoV-2 항원 검출 신속 진단 테스트 및 자가 테스트 평가: 어린이 및 성인 인구의 진단 성능 및 유용성Multicenter Study Published on 2022-09-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 치료기술, [키워드] Adults age Antigen antigen testing Chain Reaction children children COVID testing classic COVID COVID-19 diagnostic diagnostic test diagnostic testing diagnostic tests Epidemics evaluate evaluated faster Health health priorities investigated less majority multicenter multicenter study multiplex nasal Nasal sampling nasal swab nasopharyngeal sample Nasopharyngeal samples Other respiratory viruses participant performed Perspective point-of-care polymerase chain polymerase chain reaction Population Rapid diagnostic test respiratory infections respiratory viruses reverse transcriptase Reverse transcriptase polymerase chain reaction risk RT-PCR Saliva SARS-CoV-2 Self-test specificity switching transcriptase trauma Usability usability. [DOI] 10.1002/jmv.27812 PMC 바로가기 [Article Type] Multicenter Study
Actions of Novel Angiotensin Receptor Blocking Drugs, Bisartans, Relevant for COVID-19 Therapy: Biased Agonism at Angiotensin Receptors and the Beneficial Effects of Neprilysin in the Renin Angiotensin System새로운 안지오텐신 수용체 차단 약물, 비사르탄, COVID-19 치료와 관련된 작용: 안지오텐신 수용체의 편향 작용 및 레닌 안지오텐신 시스템에서 네프릴리신의 유익한 효과Article Published on 2022-07-292022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 바이오마커, [키워드] 3CLpro ACE2 Action activated activating active site Agonism ANG Ang II angiotensin angiotensin converting enzyme Angiotensin II angiotensin II receptor blockers (ARBS) angiotensin II receptors Angiotensin receptor blockers anionic ARB/NEP docking ARBs AT1 AT2 biased agonism binding biphenyl bisartans blocker blocking cells charge relay system (CRS) complementary COVID-19 COVID-19 virus DNA driven by edema Effect endopeptidase enzyme Evidence explained furin G protein Human genome humoral hypertension in silico inhibit inhibiting inverse agonist involved modulating molecular molecular dynamics Molecular dynamics (MD) mRNA neprilysin novel opposite peptide peptides Protein Pulmonary edema RAS receptor Receptor Blockers receptors Renin SARS-COV-2 infection Sartans. Screening Serine serine proteases switching System tetrazole this system Treatment Vasoactive viral entry Zinc [DOI] 10.3390/molecules27154854 PMC 바로가기 [Article Type] Article
Melatonin: Regulation of Viral Phase Separation and Epitranscriptomics in Post-Acute Sequelae of COVID-19멜라토닌: COVID-19의 급성 후유증에서 바이러스 상 분리 및 Epitranscriptomics의 조절Review Published on 2022-07-232022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료법, [키워드] Activation acute infection alteration antiviral immune response blockade change changes Concentration COVID-19 DDX3X depolarization derepression distress early infection ENhance envelope protein Epigenetic Evolution G3BP1 Genome genomic Glycolysis GSK-3 herd immunity Host host cell host genome human host immune immune responses Immunity induce Infection influence LINE1 liquid-liquid phase separation m6A maintain manifestation mechanisms melatonin membrane microenvironment mitochondrial modifications morphology nuclear nucleocapsid outcome oxidative oxidative stress PASC phase Prevent pro-inflammatory cytokine promote PROTECT regulate resulting RNA SARS-CoV-2 virus separation sequestration Signaling signaling cascades significantly Stress stress granule. stress granules Support suppress switching the SARS-CoV-2 the SARS-CoV-2 virus Transcription transcriptomic viral genome viral persistence viral replication Viral RNA virus [DOI] 10.3390/ijms23158122 PMC 바로가기 [Article Type] Review
Transitioning from Intravenous to Subcutaneous Vedolizumab in Patients with Inflammatory Bowel Disease [TRAVELESS]염증성 장 질환 환자에서 정맥 주사에서 피하 베돌리주맙으로 전환 [TRAVELESS]Article Published on 2022-07-142022-09-12 Journal: Journal of Crohn's & colitis [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Adverse drug reactions appear baseline benefit biochemical bowel calprotectin clinically Cohort cohort of patients declining Disease activity dose effective evaluate expected Health Service IBD increase in Inflammatory bowel disease injection intravenous measure offered outcome Patient Patient satisfaction reaction reason reduction reported risk factor routine clinical care Safe SARS-COV-2 infection statistically significant statistically significant difference Subcutaneous switching TRAVELESS Treatment unlikely vedolizumab vedolizumab. Week [DOI] 10.1093/ecco-jcc/jjab224 PMC 바로가기 [Article Type] Article
Has the pandemic changed treatment strategy in multiple sclerosis?대유행이 다발성 경화증의 치료 전략을 바꾸었습니까?Article Published on 2022-07-012022-09-12 Journal: Multiple sclerosis and related disorders [Category] MERS, 진단, [키워드] Affect average Care change changed changes in Cohort COVID-19 database disease disease-modifying treatment driven by dropped Efficacy Health immunosuppressive initiated lockdown Lower measure Multiple multiple sclerosis nine offset outcome pandemic Patient patients raised reduced reduction remained SARS-CoV-2 SARS-CoV-2. switching Treatment Vienna was reduced [DOI] 10.1016/j.msard.2022.103912 PMC 바로가기 [Article Type] Article